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CCSN=SS7 traf c data from working CCS subnetworks IEEE J Select Areas Commun, 12(3):544 551, 1994 A Feldmann, R Caceres, F Douglis, and M Rabinovich Performance of web proxy caching in heterogeneous bandwidth environments In Proceedings of the Conference on Computer Communications (IEEE INFOCOM), pp 107 116 April 1999 A Feldmann Impact of non-Poisson arrival sequences for call admission algorithms with and without delay In GLOBECOM'96 IEEE Global Telecommunications Conference, London, UK, 1996 A Feldmann, A Gilbert, and W Willinger Data networks as cascades: explaining the multifractal nature of internet WAN traf c In Proc ACM SIGCOMM, pp 42 55, September 1998 A Feldmann, A Gilbert, W Willinger, and T G Kurtz The changing nature of network traf c: scaling phenomena Comput Commun Rev, 28(2):5 29, 1998 H J Fowler and W E Leland Local area network traf c characteristics, with implications for broadband network congestion management.

Data from Y. Hashimoto, et al., Tox. Appl. Pharmacol. 12: 536 547, 1968. Data from J. R. Allen, et al., Pharmacol. Therap. 7: 513 547, 1979.

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virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA Nucleic Acids Res 1993, 21, 4483 4490 46 Lu, Y; Qian, X Y; Krug, R M The in uenza virus NS1 protein: a novel inhibitor of premRNA splicing Genes Dev 1994, 8, 1817 1828 47 Li, W-X; Li, H; Lu, R; Li, F; Dus, M; et al Interferon antagonist proteins of in uenza and vaccinia viruses are suppressors of RNA silencing Proc Natl Acad Sci USA 2004, 101, 1350 1355 48 Hatada, E; Saito, S; Fukuda, R Mutant in uenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells Virology 1999, 73, 2425 2433 49 Fortes, P; Beloso, A; Ortin, J In uenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport EMBO J 1994, 13, 704 712 50.

IEEE J Select Areas Commun, 9(7):1139 1149, 1991 A Feldmann, J Rexford, and R Caceres Reducing overhead in ow-switched networks: an empirical study of web traf c IEEE=ACM Trans Networking, 6:673 685, December 1998 M Grossglauser and J-C Bolot On the relevance of long-range dependence in network traf c In SIGCOMM Symposium on Communications Architectures and Protocols, pp 15 24, 1996 M W Garrett and W Willinger Analysis, modeling, and generation of self-similar VBR video traf c In SIGCOMM Symposium on Communications Architectures and Protocols, pp 269 280, 1994 Internet traf c archive http://wwwacmorg/sigcomm/ITA/indexhtml V Jacobson tcp-conn, 1996 Available through Internet Traf c Archive N L Johnson and S Kotz Distributions in Statistics: Continuous Univariate Distributions 1 Wiley-Interscience, New York, 1975 V Jacobson, C Leres, and S McCanne tcpdump, June 1989 Available via anonymous ftp to ftpeelblgov R Jain and S A.

affected by the route of administration (Table 21.3). This may be related to differences at the portals of entry or to effects on pharmacokinetic processes. In the latter case, one route (e.g., intravenous) may give rise to a concentration high enough to saturate some rate-limiting process, whereas another (e.g., subcutaneous) may distribute the dose over a longer time and avoid such saturation. Another key question is that of appropriate controls. To identify effects of handling and other stresses as well as the effects of the solvents or other carriers, it is usually better to compare treated animals with both solvent-treated and untreated or possibly sham-treated controls.

Routhier Packet trains: measurements and a new model for computer network traf c IEEE J Select Areas Commun, 4:986 995, 1986 G Kaiser A Friendly Guide to Wavelets Birkhauser, Boston, 1994 W E Leland, M S Taqqu, W Willinger, and D V Wilson On the self-similar nature of Ethernet traf c (extended version) IEEE=ACM Trans Networking, 2(1):1 15, 1994 S McCanne and V Jacobson The BSD packet lter: a new architecture for user-level packet capture In Proceedings of the 1993 Winter USENIX Conference, pp 259 269, San Diego, CA, 1993 W T Marshall and S P Morgan Statistics of mixed data traf c on a local area network Comput Networks ISDN Syst, 10:185 195, 1985 J Mogul Network behavior of a busy web server and its clients Technical Report 95=5, Digital Equipment Corp Western Research Laboratory, 1995 D S Moore.

Gale, M J; Korth, M J; Tang, N; Tan, S L; Hopkins, D A; et al Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein Virology 1997, 230, 217 227 51 Taylor, D R; Shi, S T; Romano, P R; Barber, G N; Lai, M M Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein Science 1999, 285, 107 110 52 Dever, T E; Sripriya, R; McLachlin, J R; Lu, J; Fabian-Matcher, J R; et al Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2-a kinase homolog Proc Natl Acad Sci USA 1998, 95, 4164 4169 53 McMillan, N A; Chun, R F; Siderovski, D P; Galabru, J; Toone, W.

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